Portable, high-bandwidth frequency-domain photon migration instrument for tissue spectroscopy
نویسندگان
چکیده
منابع مشابه
Portable, high-bandwidth frequency-domain photon migration instrument for tissue spectroscopy.
We describe a novel frequency-domain photon migration instrument employing direct diode laser modulation and avalanche photodiode detection, which is capable of noninvasively determinating the optical properties of biological tissues in near real time. An infinite medium diffusion model was used to extract absorption and transport scattering coefficients from 300-kHz to 800-MHz photon-density w...
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Britton Chance University of Pennsylvania Department of Biochemistry and Biophysics Philadelphia, Pennsylvania 19104 E-mail: [email protected] Abstract. We described a low-cost, frequency-domain photon migration spectroscopy instrument by using in-phase and quadrature demodulation technique in a 140-MHz homodyne system. A time constant of 1 ms was obtained. A frequency-division multiple...
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We demonstrate the use of Monte Carlo simulations to generate photon scattering density functions (PSDFs) that represent the tissue volume sampled by steady-state and frequency-domain photon migration. We use these results to illustrate how scaling laws can be developed to determine the mean sampling depth of the multiply scattered photons detected by photon migration methods that remain valid ...
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Frequency-domain photon migration (FDPM) uses modulated laser light to measure the bulk optical properties of turbid media and is increasingly applied for noninvasive functional medical imaging in the near-infrared. Although semiconductor edge-emitting laser diodes have been traditionally used as miniature light sources for this application, we show that vertical-cavity surface-emitting lasers ...
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We present the temperature dependence of absorption and reduced scattering coefficients of 1.8% Intralipid measured by frequency-domain photon-migration spectroscopy between 710 and 850 nm. These measurements were made in the physiologically relevant 30 to 40 degrees C temperature range. The temperature coefficients for absorption were consistent during heating and cooling and follow closely ot...
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ژورنال
عنوان ژورنال: Optics Letters
سال: 1994
ISSN: 0146-9592,1539-4794
DOI: 10.1364/ol.19.001934